Glycine-Mediated Paclitaxel Dispersion in a Phospholipid Complex

抄録

Paclitaxel (PTX) is one of the most widely used anticancer agents for chemotherapy. However, the solubility of PTX in water is poor, which results in the occurrence of side effects. In this study, the PTX concentration in aqueous solution was improved by naturally derived biocompatible materials, such as phospholipids (dipalmitoyl-sn-glycero-3-phosphotydilcholine, DPPC) and amino acids (AAs). The PTX concentration in phosphate-buffered saline (PBS) was increased by complexes consisting of PTX/DPPC/AAs, and glycine was found to be the most effective AA for this method. The molar ratio of PTX/DPPC/Gly was important. The ratio of DPPC to PTX was more important in increasing the concentration of PTX in PBS than the ratio of Gly to PTX. The cytotoxic effects in cancer cells were evaluated. After incubation with the PTX/DPPC/Gly complex, the viability of HeLa cells decreased. These results suggested that the PTX/DPPC/Gly complex is an efficient system for the delivery of PTX to cancer cells.