Journal of Chemical Software
Online ISSN : 1883-8359
Print ISSN : 0918-0761
ISSN-L : 0918-0761
Computer Simulation of Hydrodynamic Models for Chemical/Pharmaco-Kinetics
Setsuro SUGATAYoshihiro ABE
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2001 Volume 7 Issue 2 Pages 79-86

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Abstract

Six hydrodynamic models of typical linear chemical/pharmaco-kinetics (one containing a zero-order process) were simulated easily and realistically by computer. In particular, the pharmacokinetic simulation of a two-compartment open model with rapid intravenous injection provided many suggestions. The computer simulations were exact, and they could represent flow rate (kinetic velocity) exactly. Furthermore, the simulations could simultaneously show ordinary graphs of the variations in drug amount/concentration versus time. Therefore, they are superior to the actual hydrodynamic models in studying chemical/pharmaco-kinetics.

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© 2001 by the Chemical Software Society of Japan
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