Circulating Hepatocyte Growth Factor as a Marker of Thrombus Formation in Unstable Angina Pectoris

Akira Matsumori; Shun-ichi Miyazaki; Hajime Takano; Koh Ono; Masaharu Okada; Tadashi Miyamoto; Hiroshi Nonogi; Satoshi Daikoku; Kazuaki Mitsudo; Yoichi Matsunaga; Tomokazu Ohnishi; Yasushi Daikuhara; Shigetake Sasayama

doi:10.1253/jcj.64.805

Rapid Communication

Circulating Hepatocyte Growth Factor as a Marker of Thrombus Formation in Unstable Angina Pectoris

Akira Matsumori, Shun-ichi Miyazaki, Hajime Takano, Koh Ono, Masaharu Okada, Tadashi Miyamoto, Hiroshi Nonogi, Satoshi Daikoku, Kazuaki Mitsudo, Yoichi Matsunaga, Tomokazu Ohnishi, Yasushi Daikuhara, Shigetake Sasayama

Author information

Akira Matsumori
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
Shun-ichi Miyazaki
National Cardiovascular Center
Hajime Takano
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
Koh Ono
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
Masaharu Okada
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
Tadashi Miyamoto
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
Hiroshi Nonogi
National Cardiovascular Center
Satoshi Daikoku
National Cardiovascular Center
Kazuaki Mitsudo
Kurashiki Central Hospital
Yoichi Matsunaga
Kurashiki Central Hospital
Tomokazu Ohnishi
Department of Biochemistry, Kagoshima University Dental School, Japan
Yasushi Daikuhara
Department of Biochemistry, Kagoshima University Dental School, Japan
Shigetake Sasayama
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine

Keywords: Hepatocyte growth factor, Thrombosis, Unstable angina

JOURNAL FREE ACCESS

2000 Volume 64 Issue 10 Pages 805-807

DOI https://doi.org/10.1253/jcj.64.805

Details

Abstract

A new enzyme-linked immunosorbent assay can detect 10pg/ml of human hepatocyte growth factor (HGF). Circulating HGF was significantly higher in patients with unstable angina (296±184pg/ml, mean±SD, n=36) than in healthy volunteers (201±64pg/ml, n=250, p<0.0001). Individual concentrations exceeded the mean control value +2 SD (329pg/ml) in 12 of the 36 (33%) patients with unstable angina. The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina.

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