Circulating Hepatocyte Growth Factor as a Marker of Thrombus Formation in Unstable Angina Pectoris

Akira Matsumori; Shun-ichi Miyazaki; Hajime Takano; Koh Ono; Masaharu Okada; Tadashi Miyamoto; Hiroshi Nonogi; Satoshi Daikoku; Kazuaki Mitsudo; Yoichi Matsunaga; Tomokazu Ohnishi; Yasushi Daikuhara; Shigetake Sasayama

doi:10.1253/jcj.64.805

Rapid Communication

Circulating Hepatocyte Growth Factor as a Marker of Thrombus Formation in Unstable Angina Pectoris

Akira Matsumori, Shun-ichi Miyazaki, Hajime Takano, Koh Ono, Masaharu Okada, Tadashi Miyamoto, Hiroshi Nonogi, Satoshi Daikoku, Kazuaki Mitsudo, Yoichi Matsunaga, Tomokazu Ohnishi, Yasushi Daikuhara, Shigetake Sasayama

著者情報

キーワード: Hepatocyte growth factor, Thrombosis, Unstable angina

ジャーナルフリー

2000 年 64 巻 10 号 p. 805-807

DOI https://doi.org/10.1253/jcj.64.805

詳細

抄録

A new enzyme-linked immunosorbent assay can detect 10pg/ml of human hepatocyte growth factor (HGF). Circulating HGF was significantly higher in patients with unstable angina (296±184pg/ml, mean±SD, n=36) than in healthy volunteers (201±64pg/ml, n=250, p<0.0001). Individual concentrations exceeded the mean control value +2 SD (329pg/ml) in 12 of the 36 (33%) patients with unstable angina. The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina.

責任著者(Corresponding author)

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