JAPANESE CIRCULATION JOURNAL
Online ISSN : 1347-4839
Print ISSN : 0047-1828
ISSN-L : 0047-1828
Case Reports
Delayed Onset of Pulmonary Hypertension Associated With an Appetite Suppressant, Mazindol
- A Case Report -
Makoto HagiwaraAkihito TsuchidaMasaya HyakkokuKimio NishizatoTateki AsaiYukinaga NozawaKazufumi TsuchihashiKazuaki Shimamoto
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2000 Volume 64 Issue 3 Pages 218-221

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Abstract

The use of the appetite suppressant agents aminorex and fenfluramine derivatives has been reported as a risk factor for the development of pulmonary hypertension. A 29-year-old female developed pulmonary hypertension suspected to be due to an amphetamine-like appetite suppressant agent, mazindol ((±)-5-(p-chlorophenyl)-2, 5-dihydro-3H-imidazo [2, 1-a] isoindol-5-ol). She was admitted to Sapporo Medical University Hospital with dyspnea due to severe pulmonary hypertension. Twelve months prior to admission, she had taken mazindol continuously for a period of 10 weeks. As yet, her pulmonary hypertension has not completely improved. This is the first reported case of mazindol-associated pulmonary hypertension, which developed after a long latent interval, and it suggests that mazindol is also a risk factor for the development of pulmonary hypertension, making long-term follow-up necessary for patients taking this anorectic agent.

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© 2000 THE JAPANESE CIRCULATION SOCIETY
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