Abstract
We evaluate our clinical experience of embolization of cerebral aneurysms using Guglielmi detachable coil (GDC) technology and new direction of endovascular aneurysm therapy. Since 1990, 741 patients harboring 835 aneurysms were treated with GDC embolization at UCLA Medical Center. Immediate angiographic complete occlusion rate and long-term recanalization rate were significantly related with size of the dome and neck of the aneurysm. Overall incidence of delayed rupture was 1.4% and the rate was improved in recent 5 years (0.6%). Nine out of 11 delayed ruptures happened to large or giant aneurysms. The clinical outcomes of patients treated with GDC system have improved in the recent 5 years. However, aneurysm recanalization is still a major limitation of current GDC therapy. Utilization of tissue engineering technology and flow dynamic modification may improve current anatomical outcome.
