A Case of Solitary Fibrous Tumor of the Anterior Cranial Fossa with Intra- and Extracranial Extension

Abstract

Solitary fibrous tumor in the central nervous system is rare. We report the case of a 41-year-old man who presented with progressive dementia and a solitary fibrous tumor (SFT) arising from the dura mater of the anterior cranial fossa with intracranial and extracranial extension through the cribriform plate. The tumor was removed totally via combined transcranial and endoscopic transnasal approaches. Immunohistochemical examination of the resected specimen showed it to be strongly positive for CD34 and vimentin and negative for S-100 protein and epithelial membrane antigen (EMA), suggesting SFT. The location of the tumor and the multicystic features characterized the case. We stress the importance of including SFT in the differential diagnosis of tumors originating from the anterior cranial fossa with intracranial and extracranial extension.