Brain Metastasis of Undifferentiated Pleomorphic Sarcoma presenting with Intracerebral Hemorrhage : A Case Report and Review of the Literature

Abstract

  A 54-year-old man undergoing chemotherapy for an undifferentiated pleomorphic sarcoma of the left thigh developed sudden-onset altered consciousness. Computed tomography revealed a subcortical hemorrhage in the right frontal lobe. A hemorrhagic lesion was observed at the base of the hematoma during an emergency craniotomy. Histopathologically, spindle-shaped cells, including multinucleated giant cells, and round-shaped tumor cells, infiltrated around the blood vessels, and a brain metastasis of the undifferentiated pleomorphic sarcoma was identified. The patient died five months after the surgery due to the rapid growth of residual tumors. Brain metastases from undifferentiated pleomorphic sarcomas are rare but can cause acute cerebral hemorrhage. Therefore, this should be considered when treating patients with a history of undifferentiated pleomorphic sarcoma.