最近の研究から
二型糖尿病に関係するヒト由来グルタミン：フルクトース6リン酸アミドトランスフェラーゼの結晶解析
2009 年 51 巻 3 号 p. 195-200
詳細
2009 年 51 巻 3 号 p. 195-200
Glutamine : fructose 6-phosphate amidotransferase (GFAT) is a rate-limiting enzyme in the hexoamine biosythetic pathway and plays an important role in type 2 diabetes. We now report the first structures of the isomerase domain of the human GFAT in the presence of cyclic glucose 6-phosphate and linear glucosamine 6-phosphate. The C-terminal tail including the active site displays a rigid conformation, similar to the corresponding Escherichia coli enzyme. The diversity of the CF helix near the active site suggests the helix is a major target for drug design. Our study provides insights into the development of therapeutic drugs for type 2 diabetes.
