2013 年 55 巻 6 号 p. 340-344
γ-Glutamyltranspeptidase(GGT) is a heterodimic enzyme that undergoes post-translational processing and catalyzes the hydrolysis of γ-glutamyl bond in such compounds as glutathione and/or the transfer of the γ-glutamyl group to other amino acids and peptides. We have determined the several crystal structures of GGT orthologs and their complex structures with the substrate/product and inhibitors as well as GGT precursor. These structures demonstrate the mechanism of the maturation, catalytic reaction and substrate recognition of GGT.