日本結晶学会誌
Online ISSN : 1884-5576
Print ISSN : 0369-4585
最近の研究から
受精にかかわる精子融合因子IZUMO1と卵子受容体JUNOの認識機構の解明
石田 英子大戸 梅治清水 敏之
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ジャーナル フリー

59 巻 (2017) 2-3 号 p. 108-113

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Fertilization, the crucial step in sexual reproduction, requires the fusion of haploid sperm and egg to create a genetically distinct offspring. Despite many studies on mammalian fertilization, the molecular mechanisms underlining the membrane fusion remain largely unknown. At present, IZUMO1 on the sperm surface and JUNO on the egg surface are known as the only protein pair essential for fertilization. In this review, we focus on the crystal structures of human IZUMO1, JUNO and IZUMO1-JUNO complex. These structures reveal the molecular mechanism of mammalian gamete recognition, and provide information for development of non-hormonal contraceptive agents.

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© 2017 日本結晶学会
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