Let's Start Structural Analysis of Biomolecules with Cryo-Electron Microscopy

Abstract

About 40 years ago, the basic concept of cryo-electron microscopy was introduced, where biological specimens were kept close to nature state by being embedded in vitreous ice and observed directly with electron microscope. Since then, technology and equipment have improved significantly, making it now possible to determine the atomic coordinates of many biomolecules. Here, we will introduce the latest structural study of biomolecules using single particle cryo-electron microscopy.