クロマチンのクライオ電子顕微鏡構造解析

抄録

Chromatin is a highly organized complex of genomic DNA and proteins in eukaryotic cells. Fundamental unit of chromatin is nucleosome composed of histone octamer and approximately 150 base pairs of DNA. The higher-order conformation of chromatin is involved in important genomic events such as replication, transcription, recombination, and repair. Recently various structures chromatin have been determined by cryo-electron microscopy （cryo-EM）. Based on our cryo-EM studies, in this article, we introduce current structures of chromatin determined by cryo-EM.