2022 年 64 巻 4 号 p. 279-284
NMR methods provide information about conformational dynamics of GPCRs over a wide range of frequencies in aqueous media at near-physiological temperature, with minimal modification of the wild-type GPCR covalent structures. Here we review our solution NMR studies of the functionrelated conformational dynamics of GPCRs, including β2 adrenergic receptor, μ opioid receptor, and adenosine A2A receptor.