Synchtrotron X-ray powder diffraction and latest analysis software have increased possibilities of solving unknown structures. This article describes (a) estimation of integrated intensities by step-by-step Le Bail refinements, (b) derivation of an initial structural model by the direct method, and (c) analysis of a disordered structure by MEM-based pattern fitting. Examples of analyses with synchrotron powder data, cimetidine for (a), zeolite Linde Type L for (b), and Sr9.3Ni1.2 (PO4) 7 for (c), are shown.