日本結晶学会誌
Online ISSN : 1884-5576
Print ISSN : 0369-4585
ISSN-L : 0369-4585
新規抗マラリア薬の開発を志向したマラリア原虫由来加水分解酵素の結晶構造解析
田中 信忠
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ジャーナル フリー

2005 年 47 巻 3 号 p. 211-215

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The human malaria parasite Plasmodiiun falciparum is responsible for the death of more than a million people each year. Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (PfSAHH) inhibitors are expected to provide a new type of chemotherapeutic agent against malaria. Here we report the crystal structure of PfSAHH complexed with the reaction product adenosine. Knowledge of the structure in combination with a structural comparison with human SAHH (HsSAHH) revealed that a single amino acid substitution between the PfSAHH and HsSAHH accounts for the differential interactions with nucleoside inhibitors. The structure should provide opportunities to design selective PfSAHH inhibitors.

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