抄録
As described in this paper, the intercalation behavior of 5-fluorouracil (5-FU) into Mg-Al layered double hydroxide (LDH) was investigated using coprecipitation and ion-exchange methods. Actually, 5-FU/LDH has been characterized using element chemical analysis, powder X-ray diffraction, FT-IR spectroscopy, thermal analysis and SEM. Intercalation of 5-FU was achieved using both methods; the amount and orientation of 5-FU intercalated differed considerably by the intercalation method and co-existed anion. The d-value of 5-FU/LDH expanded to d_<003>=0.80-1.10nm, suggesting that 5-FU was intercalated into the LDH interlayer space. Results of the thermal analysis showed that the thermal stability of 5-FU was improved by intercalation in the LDH interlayer space. We propose LDH as a good host material for storage and carriage of drugs.
