Clinical study on caries inhibiting effect of stannous fluoride dentifrice containing sodium-phytate

A two-year cohort study

Abstract

In a two-year doubleblind cohort study, the caries-inhibiting effect of a dentifrice containing 0.4% stannous fluoride and 1% sodium phytate in a silica abrasive system (SnF₂-phytate dentifrice) was compared to an active control containing 0.4% stannous fluoride dentifrice and a placebo. 998 children, aged 6 to 11 years, were involved in this study.
The SnF₂-phytate dentifrice proved to be significantly effective in caries reduction when compared to both the placebo and the SnF₂ dentifrice. Reductions ranged from 21% for all teeth (ΔDMFT rate) to 47% for anterior teeth (ΔDMFT).
The SnF₂ dentifrice showed significant caries reduction for anterior teeth (40%, ΔDMFT) but not significant reduction for all teeth (9%, 21DMFT rate) in comparison with the placebo.
A significant difference was obtained in DMFS rate reduction for molar teeth between the SnF₂ dentifrice (-1%) and the SnF₂-phytate dentifrice (13%).
The results indicate that the caries-inhibiting effect of a SnF₂ dentifrice is significantly improved by the addition of sodium phytate.