Serum Levels of Insulin-like Growth Factor I, II, and Binding Protein 3, Transforming Growth Factor β-1, Soluble Fas Ligand and Superoxide Dismutase Activity in Stomach Cancer Cases and Their Controls in the JACC Study

Hiroshi Yatsuya; Hideaki Toyoshima; Koji Tamakoshi; Akiko Tamakoshi; Takaaki Kondo; Norihiko Hayakawa; Kiyomi Sakata; Shogo Kikuchi; Yoshiharu Hoshiyama; Yoshihisa Fujino; Tetsuya Mizoue; Noritaka Tokui; Takesumi Yoshimura

doi:10.2188/jea.15.S120

The Japan Collaborative Cohort Study (JACC Study) for Evaluation of Canner Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho): Report of Selected Results by Site

Serum Levels of Insulin-like Growth Factor I, II, and Binding Protein 3, Transforming Growth Factor β-1, Soluble Fas Ligand and Superoxide Dismutase Activity in Stomach Cancer Cases and Their Controls in the JACC Study

Hiroshi Yatsuya, Hideaki Toyoshima, Koji Tamakoshi, Akiko Tamakoshi, Takaaki Kondo, Norihiko Hayakawa, Kiyomi Sakata, Shogo Kikuchi, Yoshiharu Hoshiyama, Yoshihisa Fujino, Tetsuya Mizoue, Noritaka Tokui, Takesumi Yoshimura

Author information

Hiroshi Yatsuya
Department of Public Health/ Health Information Dynamics, Nagoya University Graduate School of Medicine.
Hideaki Toyoshima
Department of Public Health/ Health Information Dynamics, Nagoya University Graduate School of Medicine.
Koji Tamakoshi
Department of Public Health/ Health Information Dynamics, Nagoya University Graduate School of Medicine.
Akiko Tamakoshi
Department of Preventive Medicine/ Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine.
Takaaki Kondo
Department of Medical Technology, Nagoya University School of Health Sciences.
Norihiko Hayakawa
Department of Epidemiology, Hiroshima University Research Institute for Radiation Biology and Medicine.
Kiyomi Sakata
Department of Public Health, Wakayama Medical University.
Shogo Kikuchi
Department of Public Health, Aichi Medical University.
Yoshiharu Hoshiyama
Department of Public Health, Showa University School of Medicine.
Yoshihisa Fujino
Fukuoka Institute of Occupational Health.
Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health.
Tetsuya Mizoue
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University.
Noritaka Tokui
Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health.
Takesumi Yoshimura
Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health.
Fukuoka Institute of Health and Environmental Sciences.

Keywords: IGFs, TGFβ1, sFas, SOD, Stomach Neoplasms, Helicobacter pylori

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2005 Volume 15 Issue Supplement_II Pages S120-S125

DOI https://doi.org/10.2188/jea.15.S120

[Correction] Journal of Epidemiology Vol.15 (2005) No.5 p.197_2

Details

Abstract

BACKGROUND: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease.
METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factorβ-1 (TGFβ1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls.
RESULTS: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P = 0.013 by two-way analysis of covariance controlling for matching variable).
CONCLUSION: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.
J Epidemiol 2005; 15: S120-S125.

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