Journal of Epidemiology
Online ISSN : 1349-9092
Print ISSN : 0917-5040
Original Article
The Dose-Response Relationship Between Body Mass Index and the Risk of Incident Stage ≥3 Chronic Kidney Disease in a General Japanese Population: The Ibaraki Prefectural Health Study (IPHS)
Takehiko TsujimotoToshimi SairenchiHiroyasu IsoFujiko IrieKazumasa YamagishiHiroshi WatanabeKiyoji TanakaTakashi MutoHitoshi Ota
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2014 Volume 24 Issue 6 Pages 444-451


Purpose: To examine the relationship between body mass index (BMI) and the risk of stage ≥3 chronic kidney disease (CKD) in a general Japanese population.
Methods: A total of 105 611 participants aged 40–79 years who completed health checkups in Ibaraki Prefecture, Japan, and were free of CKD in 1993 were followed-up through 2006. Stage ≥3 CKD was defined by an estimated glomerular filtration rate <60 mL/min/1.73 m2 reported during at least 2 successive annual surveys or as treatment for kidney disease. Hazard ratios (HRs) for the development of stage ≥3 CKD relative to the BMI categories were calculated using the Cox proportional hazards regression model, which was adjusted for possible confounders and mediators.
Results: During a mean follow-up of 5 years, 19 384 participants (18.4%) developed stage ≥3 CKD. Compared to a BMI of 21.0–22.9 kg/m2, elevated multivariable-adjusted HRs were observed among men with a BMI ≥23.0 kg/m2 and women with a BMI ≥27.0 kg/m2. Significant dose-response relationships between BMI and the incidence of stage ≥3 CKD were observed in both sexes (P for trend <0.001).
Conclusions: Obesity was associated with the risk of developing stage ≥3 CKD among men and women.

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© 2014 Takehiko Tsujimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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