Journal of Epidemiology
Online ISSN : 1349-9092
Print ISSN : 0917-5040
ISSN-L : 0917-5040
The Effect of Maternal Age at the First Childbirth on Gestational Age and Birth Weight: The Japan Environment and Children’s Study (JECS)
Hyo KyozukaKeiya FujimoriMitsuaki HosoyaSeiji YasumuraTadahiko YokoyamaAkiko SatoKoichi Hashimotothe Japan Environment and Children’s Study (JECS) Group
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JOURNALS OPEN ACCESS Advance online publication

Article ID: JE20170283

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Abstract

Background: In Japan, mean maternal age at first childbirth is increasing. The aim of this study was to investigate whether maternal age at the first childbirth is a risk factor for preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA).

Methods: We used the results of Japan Environment and Children’s Study (JECS) who gave birth in 2011–2014. Cases of primiparous singleton pregnancies where the subject was ≥20 years and delivered after 22 weeks were included. All subjects were categorized into five groups according to maternal age: 20–24, 25–29, 30–34, 35–39, and ≥40 years. Adjusted odds ratios (aORs) for PTB (before 37 and 34 weeks), LBW (<2,500 g and <1,500 g), and SGA were calculated using a logistic regression model, with the 20–24-year age group as reference.

Results: We analyzed 38,412 singleton primiparous pregnancies. The aORs of all outcomes increased in parallel with each maternal age group >30 years. The aORs of PTB before 37 and 34 weeks, LBW <2,500 g, LBW <1,500 g, and SGA in the 30–34-year age group were 1.39 (95% confidence interval [CI], 1.16–1.67), 2.23 (95% CI, 1.45–3.41), 1.34 (95% CI, 1.18–1.53), 2.30 (95% CI, 1.35–3.94), and 1.24 (95% CI, 1.05–1.46), respectively.

Conclusion: The present study showed that higher maternal age (>30 years) at the first childbirth was an independent risk factor for PTB, LBW, and SGA.

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© 2018 Hyo Kyozuka et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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