Journal of Epidemiology
Online ISSN : 1349-9092
Print ISSN : 0917-5040
ISSN-L : 0917-5040
version.2
Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Junichi SugawaraMami IshikuroTaku ObaraTomomi OnumaKeiko MurakamiMasahiro KikuyaFumihiko UenoAoi NodaSatoshi MizunoTomoko KobayashiYohei HamanakaKichiya SuzukiEiichi KodamaNaho TsuchiyaAkira UrunoYoichi SuzukiOsamu TanabeHideyasu KiyomotoAkito TsuboiAtsushi ShimizuSeizo KoshibaNaoko MinegishiSoichi OgishimaGen TamiyaHirohito MetokiAtsushi HozawaNobuo FuseKengo KinoshitaShigeo KureNobuo YaegashiShinichi KuriyamaMasayuki Yamamoto
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JOURNALS OPEN ACCESS Advance online publication
Supplementary material

Article ID: JE20200338

version.2: February 18, 2021
version.1: October 10, 2020
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Abstract

Background: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants.

Methods: Expectant mothers living in Miyagi Prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group.

Results: A total of 23,406 pregnancies involving 23,730 fetuses resulted in 23,143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes, and hypertensive disorders of pregnancy.

Conclusions: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.

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© 2020 Junichi Sugawara et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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