Journal of Epidemiology
Online ISSN : 1349-9092
Print ISSN : 0917-5040
ISSN-L : 0917-5040

This article has now been updated. Please use the final version.

version.2
Disease Attribution to Multiple Exposures Using Aggregate Data
Wen-Chung LeeYun-Chun Wu
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JOURNAL OPEN ACCESS Advance online publication
Supplementary material

Article ID: JE20210084

version.2: May 21, 2022
version.1: March 12, 2022
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Abstract

Background: Identifying which exposures cause disease and quantifying their impacts is essential in promoting and monitoring public health. When multiple exposures are involved, measuring individual contributions becomes challenging.

Methods: The authors propose a disease attribution method based on aggregate data or summary statistics of individual-level data, possibly from multiple data sources.

Results: Using the proposed method, the burden of disease is apportioned to the independent and interaction effects of each of its major risk factors and all the other factors as a whole. This scheme guarantees that 100% is the total share of the burden.

Conclusion: The calculation is simple and straightforward; therefore, it is recommended for use in studies on disease burden.

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© 2022 Wen-Chung Lee et al.

This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
https://creativecommons.org/licenses/by/4.0/
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