Abstract
Quantitative and qualitative difference of the effects of life style factors ranging within the usual daily life on high density lipoprotein (HDL) were estimated in the 5th grade schoolchildren (n=155) and their parents by a cross sectional study. Strength of daily physical activity was measured directly and drinking and smoking habits, inquired by a questionnaire. By multiple linear regression analysis in the fathers, change in HDL cholesterol (HDL-C) estimated by increasing the level of strength of physical activity, body mass index, daily amount of alcohol and cigarettes from the mean of bottom tertile to that of top one was 0.08[95% confidence interval: -0.03-0.19], -0.20[-0.30oline;-0.09], 0.31[0.19oline;0.42], -0.16[-0.27oline;-0.05]mmol/liter, respectively, and that of apolipoprotein A-1 (Apo A-1), 1.1 [-2.2‾4.4], -4.4[-7.8oline;-1.1], 9.0[5.6oline;12.4], -2.4[-5.8oline;0.9]mu;mol/liter, respectively. The ratio of HDL-C to Apo A-1 increased by high activity, weight loss, alcohol, and abstaining from smoking.Although change in HDL-C and Apo A-1 due to alcohol was greatest, estimated HDL-C change accompanying a unit of estimated concentration change of Apo A-1 was smallest. These results suggested variability of HDL change in terms of its subfractional constitution, and changes induced by alcohol seemed less desirable than that induced by the other factors.Regression was borderline or insignificant in the children and mothers, who did not smoke or drink
