2017 Volume 11 Issue 1 Pages 45-49
An 83-year-old female with 2-months history of dementia and anorexia presented with erythema on her face and hands, and erosions of oral mucosa accompanied by mild fever. These symptoms appeared a week after the commencement of treatment with oral sulpiride (Dogmatyl®) at a dose of 100 mg per day. A month after the initiation of sulpiride, she was referred to our hospital with aggravation of rash and fever. At her first visit, the laboratory tests showed cytopenia, positive antinuclear antibodies (ANAs) (homogenous : × 640) , and the elevation of anti-DNA antibodies (RIA) (9.7 IU/ml) and anti-cardiolipin antibodies (72.6 U/ml) . Histopathology of erythema on her left cheek was consistent with discoid lupus erythematosus. These finding fulfilled the criteria for systemic lupus erythematosus (SLE) by American College of Rheumatology (1997) , but completely resolved after the discontinuation of sulpiride. Therefore, we diagnosed this case with a drug-induced lupus (DIL) caused by sulupiride.
