2018 年 21 巻 p. 1-6
Toll-like receptor (TLR) recognizes viral and bacterial specific components to activate immune responses. TLR plays an essential role for a pathogen sensor. TLR can be divided two groups by their localization. One is cell surface TLR which localizes in cell membrane to recognize mainly bacterial cell wall components. The other is nucleic acid-sensing TLRs, which localize in endosome or lysosome in immune cells to recognize viral and bacterial nucleic acids. We have investigated about TLR trafficking to regulate TLR7 activation. First, I want to introduce TLR4 trafficking and activation mechanism as a cell surface receptor which recognizes gram-negative bacterial cell wall component LPS. Second, I want to introduce TLR7 trafficking and activation mechanism as an endo-lysosomal TLR to recognize bacterial and viral RNAs.
