Rhoグアニンヌクレオチド交換因子によるToll様受容体シグナルの制御

【優秀演題賞】

抄録

 Toll-like receptors (TLRs) trigger innate immune responses by recognizing microbe-associated molecular patterns such as lipopolysaccharides and nucleic acids. However, overactivation or dysregulation of TLR system may lead to exaggerated inflammation and host tissue injury. TLR signaling can be controlled by other intracellular signaling, including Rho GTPases and RhoGEFs signaling. Knowledge of the molecular mechanisms underlying cross-talk of TLR and other signaling pathways can, therefore, be used for tailored therapeutic approaches to regulate local and temporal host immunity. In this review, we will focus on RhoGEFs which affect TLR signal transduction, and further we will discuss about the mechanisms of the cross-talk between TLRs and RhoGEFs. Future interests in this research field include establishing mechanistic understanding of TLRs and RhoGEFs cross-talk. This may furthermore open up novel therapeutic options for inflammatory or autoimmune diseases.