A new mouse model of sepsis using subcutaneous cecal slurry administration or intraperitoneal administration of heat-inactivated cecal slurry

Abstract

To establish a sepsis model mouse with gradual onset of symptoms that preserves the intraperitoneal drug administration route, we have created a new mouse model of sepsis using subcutaneous cecal slurry administration or intraperitoneal administration of heat-inactivated cecal slurry. Our new methods induce sepsis more slowly compared to conventional intraperitoneal administration of cecal slurry.