The protective mechanism of an initial low-dose septic challenge against lethal sepsis in neonatal mice

Abstract

Neonatal sepsis is characterized by systemic bacterial invasion followed by a massive inflammatory response. Until now, no therapeutic strategy has been established that significantly reduces the mortality from neonatal sepsis in clinical setting. Recently, we have reported the protective role of an initial low-dose septic challenge （4-days of age） in preventing subsequent lethal sepsis （7-days of age） in a neonatal mouse using cecal slurry （CS） model （Nakasone et al. JCM 2021）. In this further study, we found that the protective effect of an initial low-dose septic challenge against lethal sepsis works even with different CS stock solutions, and the effect lasts up to 2 weeks.