環境変異原研究
Online ISSN : 1880-7054
Print ISSN : 0910-0865
第33回大会シンポジウム1「発がん性と遺伝毒性の閾値-リスクアセスメントにおける問題点-」
遺伝毒性発がん物質の閾値問題
—微量でも本当に危険なのか—
福島 昭治鰐渕 英機森村 圭一朗魏 民
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2005 年 27 巻 2 号 p. 75-79

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Until recently it has been generally considered that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However, the non-threshold theory can be challenged with regard to assessment of cancer risk to humans. In the present study we show that food-related genotoxic hepatocarcinogens, heterocyclic amines and N-nitroso compounds at low doses do not induce preneoplastic lesions and cancer-related markers in rat medium-term carcinogenicity bioassay. The results imply existence of a threshold, at least practical one, for carcinogenicities of genotoxic carcinogens.

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© 2005 日本環境変異原学会
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