Total serum protein reference value as a clinical diagnostic index of equine          proliferative enteropathy

Yasushi UENO; Ryoko UEMURA; Hidekazu NIWA; Toru HIGUCHI; Satoshi SEKIGUCHI; Yosuke SASAKI; Masuo SUEYOSHI

doi:10.1294/jes.30.63

Note

Total serum protein reference value as a clinical diagnostic index of equine proliferative enteropathy

Yasushi UENO, Ryoko UEMURA, Hidekazu NIWA, Toru HIGUCHI, Satoshi SEKIGUCHI, Yosuke SASAKI, Masuo SUEYOSHI

Author information

Yasushi UENO
KM Biologics Co., Ltd., Kumamoto 860-8568, Japan
Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
Ryoko UEMURA
Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
Hidekazu NIWA
Microbiology Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan
Toru HIGUCHI
Mitsuishi Animal Medical Center, NOSAI Minami, Hokkaido 053-0021, Japan
Satoshi SEKIGUCHI
Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
Yosuke SASAKI
Department of Animal and Grassland Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
Masuo SUEYOSHI
Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

Keywords: clinical diagnostic index, equine proliferative enteropathy, Lawsonia intracellularis, total serum protein

JOURNAL FREE ACCESS

2019 Volume 30 Issue 3 Pages 63-67

DOI https://doi.org/10.1294/jes.30.63

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Abstract

Equine proliferative enteropathy (EPE) caused by Lawsonia intracellularis is characterized by hypoproteinemia. There are currently no reliable reports that provide a reference value for the total serum protein (TP) concentration to clinically diagnose EPE. The objective of this study was to statistically determine the reference value. Feces and sera of 99 foals with EPE-like clinical signs and of 35 healthy foals were obtained. The samples were used for specific-gene detection of L. intracellularis, TP measurement, and specific-antibody detection against L. intracellularis. Based on these results, the optimal reference value for the TP concentration as a clinical diagnostic index of EPE was found to be ≤ 4.8 g/dl. This clinical diagnostic index will provide an effective approach for diagnosing EPE.

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