Abstract
We previously reported the preparation of the salbutamol sulfate pulsatile-release capsules with the pH-sensitive ion exchange resin as the carriers. In the present study, we investigated the pharmacokinetics of the salbutamol sulfate pulsatile-release capsules in beagle dogs. The analysis method was established for the drugs in vivo by HPLC method. The pharmacokinetics parameters of pulsatile-release salbutamol sulfate and reference tablet were AUC0—24 (ng·h/ml) 1031.8±123.1, 1112.6±118.24, Cmax (ng/ml) 172.4±21.4, 179.3±26.1, Tmax (h) 3.8±0.6, 1.5±0.5, Tlag (h) 2.7±0.5, 0.3±0.2. The results showed that the test dosage forms was bioequivalent with reference dosage form, and had an obviously pulsatile-release effect.
