Studies on Thiamine Derivatives in Race Horse

II. Comparison among Thiamine Derivatives

Abstract

In the previous report, it was mentioned that when thiamine and Thiamine-8-(methyl-6-acetyldihydrothioctate) disulfide (TATD) were administered intravenously, TATD was maintained a high level of blood concentration for a long time. The present investigation was carried out to compare TATD with Thiamine propyl disulfide (TPD), asymmetrical disulfide derivative like TATD, and S-Benzoylthiamine OMonophosphate (BTMP), O-aryl derivative. TATD and TPD showed the same behavior, but BTMP was inferior to them with regard to the level and maintainance in the blood . This may be suggested that such asymmetrical disulfide derivatives of thiamine as TATD and TPD have a strong affinity to the red blood cell or tissues, but BTMP has a low affinity. These differences in biological activities may probably have been caused by the type of chemical bond between thiamine and its derivatives.