抄録
A new simple flow injection kinetic spectrophotometric method has been developed for the determination of famotidine in pharmaceutical preparations. The method is based on a kinetic investigation of the oxydation reaction of the drug in alkaline potassium permanganate. The absorbance of the produced green coloured manganate species was monitored at 610 nm.
Flow injection variable parameters such as reagent concentration, injected volume, reactor length and flow rate were carefully investigated and optimised. The determination of famotidine in the range of 1-50 mg L-1 was possible with a correlation coefficient of 0.9981 and a detection limit of 0.22 mg L-1. The precision of the method was within 2% for 30 mg L-1 famotidine (n=5). The flow injection method can be satisfactorily applied to the determination of famotidine in pharmaceutical preparations with a sampling frequency of 60 samples h-1.
