Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713

Satoru Kaifuchi; Mihoko Mori; Kenichi Nonaka; Rokuro Masuma; Satoshi Ōmura; Kazuro Shiomi

doi:10.2323/jgam.61.57

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Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713

Satoru Kaifuchi, Mihoko Mori, Kenichi Nonaka, Rokuro Masuma, Satoshi Ōmura, Kazuro Shiomi

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Keywords: electron transport enzyme inhibitor, NADH-fumarate reductase, Talaromyces, ukulactone

JOURNAL FREE ACCESS

2015 Volume 61 Issue 2 Pages 57-62

DOI https://doi.org/10.2323/jgam.61.57

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Abstract

Screening for NADH-fumarate reductase inhibitors led to the isolation of a new ukulactone analog, ukulactone C, as a major polyene compound produced by Talaromyces sp. FKI-6713. The structure of the compound was elucidated as a reduced analog of ukulactone A by 1D- and 2D-NMR experiments. Ukulactone C possessed a potent inhibitory activity (IC₅₀ = 62 nM) against NADH-fumarate reductase of the roundworm Ascaris suum in vitro.

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