CHEMICAL BASIS OF STREPTOMYCIN RESISTANCE IN BACILLUS SUBTILIS

Abstract

CCytological studies on the cellular components of streptomycin-sensitive strain B₃ of Bacillus subtilis and its two resistant strains 2R₂B₃ and 2R₃B₃ reveal that development of streptomycin resistance is accompanied by an increase in both DNA and RNA content of cells. The resistant strains are able to concentrate in higher amounts 13 different amino acids in the free state in the internal environment. The levels of all the amino acids and amino sugars of cell walls are higher in the resistant strains.