STUDIES ON THE RATE OF LYSINE PRODUCTION BY BREVIBACTERIUM LACTOFERMENTUM FROM GLUCOSE
1976 Volume 22 Issue 2 Pages 65-78
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1976 Volume 22 Issue 2 Pages 65-78
The production of lysine by a microbial method was studied using Brevibacterium lactofermentum (ATCC 21086) in shake flasks and a 7.5-liter fermentor. Lysine, residual glucose, cell counts, and dissolved oxygen were measured as a function of fermentation time. The effects of casamino acid, soypeptone, certain amino acids, glucose, and agitation on the rate of production and the yield were investigated. It appeared that reducing any one of the variables caused appreciable decrease in lysine production rates and yields. Plots of rate and d (log lysine)/dt were made to find the relationship between the rate of lysine production and the other factors. Plotting d (log lysine)/dt vs. lysine appears to be the most suitable method of comparing production rates. A mathematical expression was derived which appears to approximately fit the rates of lysine production.
