The Journal of General and Applied Microbiology
Online ISSN : 1349-8037
Print ISSN : 0022-1260
ISSN-L : 0022-1260
"PSEUDO-CRYSTALLOFERMENTATION" OF STEROID: A NEW PROCESS FOR PREPARING PREDNISOLONE BY A MICROORGANISM
EIJI KONDOEITARO MASUO
Author information
JOURNAL FREE ACCESS

1961 Volume 7 Issue 2 Pages 113-117

Details
Abstract

The present authors, in this paper, reported a new and a peculiar phenomenon caused by a microorganism concerning with steroidal fermentation and suggested an economical process for the industrial preparation of prednisolone from hydrocortisone. In this process the growing culture of Arthrobacter simplex ATCC 6946 was employed as microorganism, hydrocortisone in solid state was used as substrate and the fermentation was carried out aerobically in this heterogeneous phase.
The enzymic reaction of the organism proceeded onesidely to form prednisolone (Δ1-hydrocortisone), and thus, the substrate in solid form was apparently transformed into the crystals of the product in the heterogeneous reaction mixture. For this microbial reaction the authors proposed the name "pseudo-crystallofermentation."

Content from these authors
© The Microbiology Research Foundation
Previous article Next article
feedback
Top