Spontaneous Regression of Epstein-Barr Virus-negative Diffuse Large B-cell Lymphoma that Presented with Multiple Pulmonary Nodules

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A 70-year-old woman was admitted to a respiratory department because of bilateral inguinal lymphadenopathy, mediastinal lymphadenopathy, and re-growth of a nodule in the left lower lobe, which had been identified one year earlier but had regressed spontaneously over the next 6 months. After diagnostic procedures to obtain tissue from the lung and lymph nodes, she was diagnosed with Epstein-Barr virus-negative diffuse large B-cell lymphoma (DLBCL). Spontaneous regression or remission of lung involvement in a patient with DLBCL has rarely been reported and the precise mechanism is unknown, but this case clearly demonstrated regression and re-growth of the lung nodules during her clinical course.