The association between higher intake of sucrose and depression

Abstract

We aimed to clarify the influence of increase of sucrose intake on depression-like behavior in mice. Mice in the control group were fed solid feed containing 10% sucrose, and mice in the experimental group were fed solid feed containing 20% sucrose. After feeding for 4 weeks and 26 weeks, forced swim test was performed, and immobility times were measured. In addition, body weight and fasting blood glucose were measured after 4 weeks and 26 weeks, and weight of feces a day was measured only after 26 weeks. There were no significant differences in immobility time, body weight, fasting blood glucose, and feces weight between the experimental group and the control group. Our findings suggest that increase of sucrose intake in mice does not cause depression-like behavior.