Abstract
Type 2 Diabetes has enormously increased for the last few decades in Japan. It is one of the life-style related diseases and prevention is thought to be very important to reduce it. We examined health check-up data longitudinally and tried to reveal the risk factors and find the natural course of the onset of the disease. Normal fasting plasma glucose (FPG) group (n=11, 123, age: 41.9±7.1) have been followed up for more than 10 years. Among them, 8.6% became diabetes (DM group, FPG≥126 mg/dl) and 24.9% became Impaired Glucose Tolerance (IGT group, 110≤FPG<126) in 14 years. DM group and IGT group had significantly high FPG, BMI, ALT and triglyceride level during the observation period. Multiple regression tests (Stepwise method) revealed the significant relation between the last FPG value and FPG initial, BMI, ALT and triglyceride. According to Cox model, FPG level initial might be crucial, even if it was within normal range. If FPG were from 90 to 94 mg/dl, 10% would become diabetes in next two decades, but if FPG were from 105 to 109 mg/dl, 46% would become diabetes in the same period.
