The Effect of Ca- and H₅-DTPA Administered by Various Routes on the Removal of ⁵⁹Fe from the Rat Lung Instilled with ⁵⁹Fe-iron Dextran

Abstract

To assess the possibility of application of H₅-DTPA for the chelating treatment in the accidental contamination with radioactive metal elements, the experimental treatments with Ca- and H₅-DTPA were carried out in rats of which lungs were instilled with ⁵⁹Fe-iron dextran. After the instillation, the animals were treated by DTPA on the 2nd day and sacrificed on the 7th day. The lung retention of ⁵⁹Fe was significantly decreased and the urinary excretion was remarkably increased by the intratracheal instillation of Ca-DTPA at doses of 30 and 300μmol/rat. While the intratracheal instillation of H₅-DTPA of 30, 100 and 150μmol/rat significantly increased the urinary excretion of ⁵⁹Fe, its effectiveness was about half that of Ca-DTPA. On the other hand, no significant change was observed after either the subcutaneous implantation of H₅-DTPA or intraperitoneal injection of Ca-DTPA at the same dose level.