種々の経路で投与した¹⁴⁴Ceのラットにおける排泄および体内分布

抄録

Urinary and fecal excretion of ¹⁴⁴Ce was studied for 15 days following subcutaneous, intramuscular, intraperitoneal and intravenous injection of ¹⁴⁴CeCl₃ to the rat. From the third to the 15th day, the daily urinary excretion of ¹⁴⁴Ce following all the routes of administration was expressed in the first approximation by a single exponential function, regardless of the difference of the routes. It means that the initial body burden of ¹⁴⁴Ce can be estimated from the daily urinary excretion of ¹⁴⁴Ce during this period using an identical formula.
Tissue distribution of ¹⁴⁴Ce 15 days postinjection was also studied. After 15 days following subcutaneous and intramuscular injection, 57 and 38 percent of the injected ¹⁴⁴Ce were found at the sites of injection, respectively. The transported ¹⁴⁴Ce was deposited mainly in the liver and bone regardless of the routes of administration.