Journal of Hard Tissue Biology
Online ISSN : 1880-828X
Print ISSN : 1341-7649
ISSN-L : 1341-7649
International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005
Vitamin K can Suppress the Inflammation Induced by Lipopolysaccharide Administration.
Hitoshi ShirakawaYusuke OhsakiKazuyuki HiwatashiYuji FurukawaTakeo MizutaniMichio Komai
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2005 Volume 14 Issue 2 Pages 284-285


Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of g-carboxyglutamic acid from glutamic acid residues. In addition to liver and bone, K is found in brain, heart, kidney and gonadal tissue. However, the physiological role of K in these varied organs is not yet fully understood. It is likely that K has functions in addition to its role as a cofactor of protein g-glutamyl carboxylation. In this paper we used DNA microarray techniques to identify the effect of K status on gene expression in rat liver. Expression of genes involved in the acute inflammation response was enhanced in rats fed a K-deficient diet relative to control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed inflammation induced by LPS administration. These results indicate that orally administrated K1 suppresses inflammation in the rat.

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© 2005 by The Hard Tissue Biology Network Association(JHTBNet)
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