Journal of Hard Tissue Biology
Online ISSN : 1880-828X
Print ISSN : 1341-7649
ISSN-L : 1341-7649
International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005
Vitamin K can Suppress the Inflammation Induced by Lipopolysaccharide Administration.
Hitoshi ShirakawaYusuke OhsakiKazuyuki HiwatashiYuji FurukawaTakeo MizutaniMichio Komai
Author information

2005 Volume 14 Issue 2 Pages 284-285


Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of g-carboxyglutamic acid from glutamic acid residues. In addition to liver and bone, K is found in brain, heart, kidney and gonadal tissue. However, the physiological role of K in these varied organs is not yet fully understood. It is likely that K has functions in addition to its role as a cofactor of protein g-glutamyl carboxylation. In this paper we used DNA microarray techniques to identify the effect of K status on gene expression in rat liver. Expression of genes involved in the acute inflammation response was enhanced in rats fed a K-deficient diet relative to control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed inflammation induced by LPS administration. These results indicate that orally administrated K1 suppresses inflammation in the rat.

Information related to the author
© 2005 by The Hard Tissue Biology Network Association(JHTBNet)
Previous article Next article