Identification of the Genomic Structure of Tumor Suppressor ING1 and Mutation Analysis in Head and Neck Squamous Cell Carcinomas

Mehmet Gunduz; Esra Gunduz; Byung-Moo Min; Gene Lee; Ji-Jun Lim; Kenji Shimizu; Takeyuki Katayama; Noriyuki Nagai

doi:10.2485/jhtb.14.320

International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005

Identification of the Genomic Structure of Tumor Suppressor ING1 and Mutation Analysis in Head and Neck Squamous Cell Carcinomas

Mehmet Gunduz, Esra Gunduz, Byung-Moo Min, Gene Lee, Ji-Jun Lim, Kenji Shimizu, Takeyuki Katayama, Noriyuki Nagai

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Keywords: Head and neck squamous cell carcinoma, Loss of heterozygosity (LOH), Bacterial artificial chromosome (BAC), SSCP

JOURNAL FREE ACCESS

2005 Volume 14 Issue 2 Pages 320-321

DOI https://doi.org/10.2485/jhtb.14.320

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Abstract

A candidate tumor suppressor gene, ING1 has been recently cloned and mapped to 13q33-34 region. We characterized the genomic structure of the human ING1 gene and detected somatic mutations of the ING1 gene in head and neck squamous cell carcinomas. 23 out of 34 informative cases (68%) of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. By sequence analysis three exons and 2 introns of ING1 were identified. Mutation analysis of ING1 gene showed three missense and three silent changes.

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