A Protective Function of the Calcium Binding Protein S100A4 in Rat Hepatic Injury Due to Carbon Tetrachloride

Abstract

F The role of the S100A4 in rat hepatocites was clarified by measuring detailed changes in serum ALT values and intracellular Ca²⁺ after CCl₄ administration. In this study, we further showed that the calcium binding protein S100A4 might be a protein signal involved in the response to protect cells against CCl₄ intoxication. S100A4 mRNA expression levels abruptly increased to a high level in normal liver at 1 day after CCl₄ administration, and then gradually reduced to the control level by day 3. This change is the opposite to that of intracellular Ca²⁺.