Wnt5a Gene Plays a Role in Mouse Embryonic Orofacial Development

Jing Xiao; En-xin Zhu; Hitoshi Nagatsuka; Mehmet Gunduz; Changgong Li; Parviz Minoo; Noriyuki Nagai

doi:10.2485/jhtb.14.355

International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005

Wnt5a Gene Plays a Role in Mouse Embryonic Orofacial Development

Jing Xiao, En-xin Zhu, Hitoshi Nagatsuka, Mehmet Gunduz, Changgong Li, Parviz Minoo, Noriyuki Nagai

Author information

Jing Xiao
Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Department of Oral Pathology, College of Stomatology, Dalian Medical University
En-xin Zhu
Department of Oral Pathology, College of Stomatology, Dalian Medical University
Hitoshi Nagatsuka
Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Mehmet Gunduz
Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Changgong Li
Department of Pediatrics, Keck School of Medicine, University of Southern California
Parviz Minoo
Department of Pediatrics, Keck School of Medicine, University of Southern California
Noriyuki Nagai
Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Keywords: Wnt5a, Development, Palate, Gene, KO mouse

JOURNAL FREE ACCESS

2005 Volume 14 Issue 4 Pages 355-356

DOI https://doi.org/10.2485/jhtb.14.355

Details

Abstract

To determine if Wnt5a gene involved in orofacial development, especially secondary palate development, we checked Wnt5a protein and mRNA in wild-type mouse embryos, and also searched Wnt5a knockout mice palates. We found Wnt5a is expressed during orofacial development, especially necessary for normal secondary palate and tongue morphogenesis. Wnt5a deficient mice exhibit cleft palate and abnormal distortion tongue suggests Wnt5a is essential to the palate development. Our data suggested that defection of MEE proliferation in Wnt5a (-/-) secondary palate indicates Wnt5a gene may regulate palate growth.

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