Journal of Hard Tissue Biology
Online ISSN : 1880-828X
Print ISSN : 1341-7649
ISSN-L : 1341-7649
Review
Transforming Growth Factor Beta (TGF-β) Gene Family Members in Developing and Neoplastic Odontogenic Tissues
Kristiina HeikinheimoKazuhisa MoriHitoshi NagatsukaRisto-Pekka Happonen
著者情報
ジャーナル フリー

2006 年 15 巻 1 号 p. 1-5

詳細
抄録
During the last decade, several molecules regulating tooth development have been identified (http://bite-it.helsinki.fi/). Especially members of the transforming growth factor beta (TGF-β) supergene family, structurally relates cytokines, are essential for teeth to develop. These include TGF-βs, activin A, bone morphogenetic proteins (BMPs), and their cell surface receptors. In addition, follistatin, an extracellular protein that interacts with activin and BMP signalling, appears to be an important mediator of associated inductive signals. Enhanced or impaired TGF-β/BMP signalling may play a role in odontogenic tumorigenesis. This review focuses on findings of our studies on the roles played by of TGF-β receptors, their ligands and extracellular modifiers during tooth development and in odontogenic tumours.
著者関連情報
© 2006 by The Hard Tissue Biology Network Association(JHTBNet)
次の記事
feedback
Top