Immunohistochemical Observation of BMP in the Mouse Orthodontic Periodontal Tension Sides

Abstract

The purpose of this examination was to in vestigate the expression of BMP-2 and -4 in mouse orthodontic periodontal tension sides exposed orthodontic mechanical stress using the method of Waldo. Immnohistochemically, in the experimental group, strong expression of BMP-2 and -4 were observed in the periodontal tension sides at 20minutes. The results strongly suggested that the BMP-2 and -4 promoted the Runx2 expression for osteoblastic differention in the orthodontic periodontal tension sides at the early stage after receiving of the mechanical stress.