2018 年 27 巻 4 号 p. 295-302
Objective: This study aims to synthesize a new biodegradable and biomineralized guided bone regeneration membrane. Experimental Methods: Poly(propylene carbonate) (PPC) and nanohydroxyapatite (nHAp) were prepared by solvent casting/particulate leaching and made into membranes with different compositions (0%,10%,20%, 30%, and 40% nHAp/PPC). Their mechanical properties, cell compatibilities and fibroblast barrier functions were studied in vitro. Results: Scanning electron microscopy showed that the nHAp/PPC membrane displayed a smooth and rough surface similar to that of periosteal structure. Tensile test results indicated that the tensile strengths of 10% and 20% nHAp/PPC groups were significantly higher than that of 0% nHAp/PPC group. With the increased nHAp content, the tensile strength of nHAp/PPC membrane and the hydrophilic angle were decreased, and the mineralization ability in vitro was enhanced. After 4 weeks of degradation in vitro, only 40% of the nHAp/PPC group exhibited significantly higher rate of weight loss than that of the 0% nHAp/PPC group. Additionally, scanning electron microscopy showed that MG63 cells adhered to the rough surface of the nHAp/PPC membrane. Five groups of nHAp/PPC membranes showed good fibroblast barrier in vitro .Taken together, this in vitro evaluation suggests that the nHAp/PPC membrane is suitable as a guided bone regeneration membrane.
